*◊ Herman, Kleiner-Goudey, Davis: Advances in Ophthalmology and Visual System: January, 2017
*◊ Richer SP, Stiles W, Graham-Hoffman K, Levin M, Ruskin D, Wrobel J, Park DW, Thomas C. Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973. Optometry. 2011 Nov;82(11):667-680.e6. doi: 10.1016/j.optm.2011.08.008. PMID: 22027699.
*Olk RJ, Peralta E, Gierhart DL, Brown GC, Brown MM. Triple combination therapy and zeaxanthin for the treatment of neovascular age-related macular degeneration: an interventional comparative study and cost-effectiveness analysis. Int J Retina Vitreous. 2015 Nov 9;1:22. doi:10.1186/s40942-015-0019-2. PMID: 27847615; PMCID: PMC5088486.
*◊ Macular Re-pigmentation Enhances Driving Vision in Elderly Adult Males with Macular Degeneration (Richer, et. al. - Clinical & Experimental Ophthalmology, 2012)
**Dorey CK, Gierhart D, Fitch KA, Crandell I, Craft NE. Low Xanthophylls, Retinol, Lycopene, and Tocopherols in Grey and White Matter of Brains with Alzheimer's Disease. J Alzheimers Dis. 2023;94(1):1-17. doi: 10.3233/JAD-220460. PMID: 35988225; PMCID: PMC10357197.
**The Effects of Lutein and Zeaxanthin Supplementation on Cognitive Function in Adults With Self-Reported Mild Cognitive Complaints: A Randomized, Double-Blind, Placebo-Controlled Study. J Frontiers of Nutrition 2022; 9:22. https://www.frontiersin.org/journals/nutrition/articles/10.3389/fnut.2022.843512
**◊ Renzi-Hammond, L.M.; Bovier, E.R.; Fletcher, L.M.; Miller, L.S.; Mewborn, C.M.; Lindbergh, C.A.; Baxter, J.H.; Hammond, B.R. Effects of a Lutein and Zeaxanthin Intervention on Cognitive Function: A Randomized, Double-Masked, Placebo-Controlled Trial of Younger Healthy Adults. Nutrients 2017, 9, 1246. https://doi.org/10.3390/nu9111246
**◊ Mewborn, C.M.; Lindbergh, C.A.; Robinson, T.L.; Gogniat, M.A.; Terry, D.P.; Jean, K.R.; Hammond, B.R.; Renzi-Hammond, L.M.; Miller, L.S. Lutein and Zeaxanthin Are Positively Associated with Visual–Spatial Functioning in Older Adults: An fMRI Study. Nutrients 2018, 10, 458. https://doi.org/10.3390/nu10040458
**◊ A Double-Blind, Placebo-Controlled Study on the Effects of Lutein and Zeaxanthin on Neural Processing Speed and Efficiency Bovier ER, Renzi LM, Hammond BR (2014) A Double-Blind, Placebo-Controlled Study on the Effects of Lutein and Zeaxanthin on Neural Processing Speed and Efficiency. PLOS ONE 9(9): e108178. https://doi.org/10.1371/journal.pone.0108178
***Juturu V, Bowman JP, Deshpande J. Overall skin tone and skin-lightening-improving effects with oral supplementation of lutein and zeaxanthin isomers: a double-blind, placebo-controlled clinical trial. Clin Cosmet Investig Dermatol. 2016 Oct 7;9:325-332. doi: 10.2147/CCID.S115519. PMID: 27785083; PMCID: PMC5063591.
***Roberts RL, Green J, Lewis B. Lutein and zeaxanthin in eye and skin health. Clin Dermatol. 2009 Mar-Apr;27(2):195-201. doi: 10.1016/j.clindermatol.2008.01.011. PMID: 19168000.
***Schwartz S, Frank E, Gierhart D, Simpson P, Frumento R. Zeaxanthin-based dietary supplement and topical serum improve hydration and reduce wrinkle count in female subjects. J Cosmet Dermatol. 2016 Dec;15(4):e13-e20. doi: 10.1111/jocd.12226. Epub 2016 Jun 17. PMID: 27312122.
***González S, Astner S, An W, Goukassian D, Pathak MA. Dietary lutein/zeaxanthin decreases ultraviolet B-induced epidermal hyperproliferation and acute inflammation in hairless mice. J Invest Dermatol. 2003 Aug;121(2):399-405. doi: 10.1046/j.1523-1747.2003.12355.x. PMID: 12880433.
****Stringham JM, Stringham NT, O'Brien KJ. Macular Carotenoid Supplementation Improves Visual Performance, Sleep Quality, and Adverse Physical Symptoms in Those with High Screen Time Exposure. Foods. 2017 Jun 29;6(7):47. doi: 10.3390/foods6070047. PMID: 28661438; PMCID: PMC5532554.
****A. Chang, D. Aeschbach, J.F. Duffy, & C.A. Czeisler, Evening use of light-emitting eReaders negatively affects sleep, circadian timing, and next-morning alertness, Proc. Natl. Acad. Sci. U.S.A. 112 (4) 1232-1237, https://doi.org/10.1073/pnas.1418490112 (2015).
◊ Richer, S.; Novil, S.; Gullett, T.; Dervishi, A.; Nassiri, S.; Duong, C.; Davis, R.; Davey, P.G. Night Vision and Carotenoids (NVC): A Randomized Placebo Controlled Clinical Trial on Effects of Carotenoid Supplementation on Night Vision in Older Adults. Nutrients 2021, 13, 3191. https://doi.org/10.3390/nu13093191
^https://www.kalsec.com/zeaxanthin
^https://www.kemin.com/na/en-us/markets/human-nutrition/products/carotenoids/floraglo-lutein
^^Arnold C, Winter L, Fröhlich K, et al. Macular Xanthophylls and ω-3 Long-Chain Polyunsaturated Fatty Acids in Age-Related Macular Degeneration: A Randomized Trial. JAMA Ophthalmol. 2013;131(5):564–572. doi:10.1001/jamaophthalmol.2013.2851
^^Christen WG, Schaumberg DA, Glynn RJ, Buring JE. Dietary ω-3 fatty acid and fish intake and incident age-related macular degeneration in women. Arch Ophthalmol. 2011 Jul;129(7):921-9. doi: 10.1001/archophthalmol.2011.34. Epub 2011 Mar 14. PMID: 21402976; PMCID: PMC3134638.
^^Dawczynski J, Jentsch S, Schweitzer D, Hammer M, Lang GE, Strobel J. Long term effects of lutein, zeaxanthin and omega-3-LCPUFAs supplementation on optical density of macular pigment in AMD patients: the LUTEGA study. Graefes Arch Clin Exp Ophthalmol. 2013 Dec;251(12):2711-23. doi: 10.1007/s00417-013-2376-6. Epub 2013 May 22. PMID: 23695657.
^^Chan HN, Zhang XJ, Ling XT, Bui CH, Wang YM, Ip P, Chu WK, Chen LJ, Tham CC, Yam JC, Pang CP. Vitamin D and Ocular Diseases: A Systematic Review. Int J Mol Sci. 2022 Apr 11;23(8):4226. doi: 10.3390/ijms23084226. PMID: 35457041; PMCID: PMC9032397.
^^Cunningham ET Jr, Sobrin L, Hall AJ, Zierhut M. Vitamin D and Ocular Inflammation. Ocul Immunol Inflamm. 2020 Apr 2;28(3):337-340. doi: 10.1080/09273948.2020.1734421. PMID: 32255412.
^^Layana AG, Minnella AM, Garhöfer G, Aslam T, Holz FG, Leys A, Silva R, Delcourt C, Souied E, Seddon JM. Vitamin D and Age-Related Macular Degeneration. Nutrients. 2017 Oct 13;9(10):1120. doi: 10.3390/nu9101120. PMID: 29027953; PMCID: PMC5691736.
^^Tohari AM, Alhasani RH, Biswas L, Patnaik SR, Reilly J, Zeng Z, Shu X. Vitamin D Attenuates Oxidative Damage and Inflammation in Retinal Pigment Epithelial Cells. Antioxidants (Basel). 2019 Aug 24;8(9):341. doi: 10.3390/antiox8090341. PMID: 31450606; PMCID: PMC6770403.